p18 Rabbit pAb
-YT3495
主要信息
Target
p18
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey
Applications
WB, IHC, IF, ELISA
MW
18kD (Observed)
Conjugate/Modification
Unmodified
货号: YT3495
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
p18 Polyclonal Antibody detects endogenous levels of p18 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
18kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human p18 INK. AA range:111-160
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特异性:
p18 Polyclonal Antibody detects endogenous levels of p18 protein.
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基因名称:
CDKN2C
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蛋白名称:
Cyclin-dependent kinase 4 inhibitor C
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别名:
CDKN2C ;
CDKN6 ;
Cyclin-dependent kinase 4 inhibitor C ;
Cyclin-dependent kinase 6 inhibitor ;
p18-INK4c ;
p18-INK6
CDKN6 ;
Cyclin-dependent kinase 4 inhibitor C ;
Cyclin-dependent kinase 6 inhibitor ;
p18-INK4c ;
p18-INK6
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背景:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6 , and prevent the activation of the CDK kinases , thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis , as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene , which encode an identical protein , have been reported. [provided by RefSeq , Jul 2008] ,
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功能:
Disease:Defects in CDKN2C are involved in tumor formation. ,Function:Interacts strongly with CDK6 , weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. ,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. ,similarity:Contains 4 ANK repeats. ,subunit:Heterodimer of p18 with CDK6. ,tissue specificity:Highest levels found in skeletal muscle. Also found in pancreas and heart. ,
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细胞定位:
nucleus ,cytoplasm ,cytosol ,
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研究领域:
>>Endocrine resistance ;
>>Cell cycle ;
>>Cushing syndrome ;
>>Human T-cell leukemia virus 1 infection ;
>>Transcriptional misregulation in cancer
>>Cell cycle ;
>>Cushing syndrome ;
>>Human T-cell leukemia virus 1 infection ;
>>Transcriptional misregulation in cancer
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信号通路
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货号: YT3495
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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