The antiserum was produced against synthesized peptide derived from human RBL1. AA range:335-384

p107 Polyclonal Antibody detects endogenous levels of p107 protein.

RBL1

Retinoblastoma-like protein 1

RBL1 ;
Retinoblastoma-like protein 1 ;
107 kDa retinoblastoma-associated protein ;
p107 ;
pRb1

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation , as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen , with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition , both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein , it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms hav

Function:Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and , in particular , that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2 , leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. ,PTM:Exists in both phosphorylated and unphosphorylated forms , and T , but not E1A , binds only to the unphosphorylated form. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332 , Ser-640 , Ser-964 and Ser-975 by CDK4. ,similarity:Belongs to the retinoblastoma protein (RB) family. ,subunit:Interacts with SUV420H1 and SUV420H2 (By similarity) . Component of the DREAM complex (also named LINC complex) at least composed of E2F4 , E2F5 , LIN9 , LIN37 , LIN52 , LIN54 , MYBL1 , MYBL2 , RBL1 , RBL2 , RBBP4 , TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9 , LIN37 , LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with SV40 and JC virus large T antigens. ,

Nucleus .

>>Cell cycle ;
>>Cellular senescence ;
>>TGF-beta signaling pathway ;
>>Human papillomavirus infection ;
>>Viral carcinogenesis