ER81 Rabbit pAb
-YT1604
主要信息
Target
ER81
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
货号: YT1604
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
ER81 Polyclonal Antibody detects endogenous levels of ER81 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human ER81. AA range:10-59
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特异性:
ER81 Polyclonal Antibody detects endogenous levels of ER81 protein.
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基因名称:
ETV1
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蛋白名称:
ETS translocation variant 1
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别名:
ETV1 ;
ER81 ;
ETS translocation variant 1 ;
Ets-related protein 81
ER81 ;
ETS translocation variant 1 ;
Ets-related protein 81
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背景:
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth , angiogenesis , migration , proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region , in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations , which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377 , Table 1) in prostate cancer. In addition to chromosomal rearrangement , this gene is overexpressed in prostate cancer , melanoma and gastrointestinal stromal tumor. Multiple alte
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功能:
Disease:A chromosomal aberration involving ETV1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t (7;22) (p22;q12) with EWS. ,Function:Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. ,PTM:Sumoylated. ,similarity:Belongs to the ETS family. ,similarity:Contains 1 ETS DNA-binding domain. ,tissue specificity:Very highly expressed in brain , highly expressed in testis , lung and heart , moderately in spleen , small intestine , pancreas and colon , weakly in liver , prostate and thymus , very weakly in skeletal muscle , kidney and ovary and not in placenta and peripheral blood leukocytes. ,
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细胞定位:
Nucleus .
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研究领域:
>>Transcriptional misregulation in cancer
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文献引用（{{totalcount}}）
货号: YT1604
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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