Endogenous

AURKC

Serine/threonine-protein kinase 13/Aurora kinase C

AIE2 ;
AIK3 ;
AIRK3 ;
ARK3 ;
STK13 ;
Aurora kinase C ;
Aurora 3 ;
Aurora/IPL1 related kinase 3 ;
ARK 3 ;
Aurora related kinase 3 ;
Serine/threonine protein kinase 13 ;
Aurora/IPL1related kinase 3 ;
Aurorarelated kinase 3 ;
Serine/threonineprotein kinase 13 ;
Serine/threonineprotein kinase auroraC ;

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle,Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.