Disease:Autoantigen in the paraneoplastic opsoclonus myoclonus ataxia (POMA) , a paraneoplastic neurological syndrome/disorder (PNS/D) associated with breast cancer , fallopian cancer , and SCLCa and characterized primarily by loss of inhibitory control of motor neurons in the spinal cord and brainstem. Recognized by the IgG autoantibody ANNA-2 (also called anti-Ri) . ,Domain:The third KH domain (KH3) recognizes specifically 5'-UCAY-3'. ,Function:May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity) . Binds single strand RNA. ,similarity:Contains 3 KH domains. ,subunit:Interacts with PTBP2. ,tissue specificity:Brain. Expression restricted to astrocytes. ,
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