Function:Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.,PTM:Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination.,PTM:Ubiquitinated; leading to degradation by the proteasome.,similarity:Contains 1 KBD domain.,similarity:Contains 1 SPR (sprouty) domain.,similarity:Contains 1 WH1 domain.,subcellular location:Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.,subunit:Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers.,tissue specificity:Expressed in liver, skin, small intestine, salivary gland and prostate.,
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