Synthesized peptide derived from human DUSP4 Polyclonal

This antibody detects endogenous levels of DUSP4.

DUSP4 MKP2 VH2

Dual specificity protein phosphatase 4 (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)

Dual specificity protein phosphatase 4 ;
EC 3.1.3.48 ;
Dual specificity protein phosphatase hVH2 ;
Mitogen-activated protein kinase phosphatase 2 ;
MAP kinase phosphatase 2 ;
MKP-2 ;

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been obser

Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

Nucleus .

Skin,Uterus,

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