Synthetic peptide from human protein at AA range: 377-451

The antibody detects endogenous PLK2

PLK2 SNK

PLK2

Serine/threonine-protein kinase PLK2 ;
Polo-like kinase 2 ;
PLK-2 ;
hPlk2 ;
Serine/threonine-protein kinase SNK ;
hSNK ;
Serum-inducible kinase ;

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 POLO box domains.,

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, dendrite . Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.

Expressed at higher level in the fetal lung, kidney, spleen and heart.

>>FoxO signaling pathway