CYPA Rabbit pAb
-YT5197
主要信息
Target
CYPA
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
18kD (Observed)
Conjugate/Modification
Unmodified
货号: YT5197
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
CyPA Polyclonal Antibody detects endogenous levels of CyPA protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
18kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from the Internal region of human PPIA. AA range:51-100
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特异性:
CyPA Polyclonal Antibody detects endogenous levels of CyPA protein.
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基因名称:
PPIA
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蛋白名称:
Peptidyl-prolyl cis-trans isomerase A
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别名:
PPIA ;
CYPA ;
Peptidyl-prolyl cis-trans isomerase A ;
PPIase A ;
Cyclophilin A ;
Cyclosporin A-binding protein ;
Rotamase A
CYPA ;
Peptidyl-prolyl cis-trans isomerase A ;
PPIase A ;
Cyclophilin A ;
Cyclosporin A-binding protein ;
Rotamase A
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背景:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.,Function:PPIases accelerate the folding of proteins.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subunit:Interacts with HIV-1 Capsid protein.,
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细胞定位:
Cytoplasm . Secreted . Nucleus . Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation. .
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研究领域:
>>Viral life cycle - HIV-1 ;
>>Necroptosis
>>Necroptosis
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货号: YT5197
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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