UFD2 Rabbit pAb
-YT4818
主要信息
Target
UFD2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
146kD (Calculated)
Conjugate/Modification
Unmodified
货号: YT4818
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
UFD2 Polyclonal Antibody detects endogenous levels of UFD2 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
146kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from the Internal region of human UFD2.
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特异性:
UFD2 Polyclonal Antibody detects endogenous levels of UFD2 protein.
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基因名称:
UBE4B
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蛋白名称:
Ubiquitin conjugation factor E4 B
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别名:
UBE4B ;
HDNB1 ;
KIAA0684 ;
UFD2 ;
Ubiquitin conjugation factor E4 B ;
Homozygously deleted in neuroblastoma 1 ;
Ubiquitin fusion degradation protein 2
HDNB1 ;
KIAA0684 ;
UFD2 ;
Ubiquitin conjugation factor E4 B ;
Homozygously deleted in neuroblastoma 1 ;
Ubiquitin fusion degradation protein 2
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背景:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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功能:
Function:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,PTM:Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,subunit:Interacts with VCP.,tissue specificity:Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.,
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细胞定位:
Cytoplasm . Nucleus .
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组织表达:
Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788).
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研究领域:
>>Ubiquitin mediated proteolysis ;
>>Protein processing in endoplasmic reticulum
>>Protein processing in endoplasmic reticulum
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信号通路
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货号: YT4818
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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