UDP-GlcDH Rabbit pAb
-YT4816
主要信息
Target
UDP-GlcDH
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
55kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4816
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human UGDH. AA range:391-440
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特异性:
UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.
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基因名称:
UGDH
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蛋白名称:
UDP-glucose 6-dehydrogenase
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别名:
UGDH ;
UDP-glucose 6-dehydrogenase ;
UDP-Glc dehydrogenase ;
UDP-GlcDH ;
UDPGDH
UDP-glucose 6-dehydrogenase ;
UDP-Glc dehydrogenase ;
UDP-GlcDH ;
UDPGDH
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背景:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
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功能:
Catalytic activity:UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.,Function:Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.,pathway:Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.,similarity:Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.,subunit:Homohexamer.,
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细胞定位:
nucleus,nucleoplasm,cytosol,extracellular exosome,
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组织表达:
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
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研究领域:
>>Pentose and glucuronate interconversions ;
>>Ascorbate and aldarate metabolism ;
>>Amino sugar and nucleotide sugar metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors ;
>>Biosynthesis of nucleotide sugars
>>Ascorbate and aldarate metabolism ;
>>Amino sugar and nucleotide sugar metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors ;
>>Biosynthesis of nucleotide sugars
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文献引用（{{totalcount}}）
货号: YT4816
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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