Topoisomerase IIα Rabbit pAb
-YT4701
主要信息
Target
Topo IIα
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, IF, ELISA
MW
174kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4701
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Topo IIα Polyclonal Antibody detects endogenous levels of Topo IIα protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
174kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human TOP2A. AA range:1-50
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特异性:
Topo IIα Polyclonal Antibody detects endogenous levels of Topo IIα protein.
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基因名称:
TOP2A TOP2
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蛋白名称:
DNA topoisomerase 2-alpha
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别名:
TOP2A ;
TOP2 ;
DNA topoisomerase 2-alpha ;
DNA topoisomerase II ;
alpha isozyme
TOP2 ;
DNA topoisomerase 2-alpha ;
DNA topoisomerase II ;
alpha isozyme
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背景:
This gene encodes a DNA topoisomerase , an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation , chromatid separation , and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another , thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form , alpha , is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
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功能:
Catalytic activity:ATP-dependent breakage , passage and rejoining of double-stranded DNA. ,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine. ,Function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. ,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils , whereas prokaryotic enzymes relax only negative supercoils. ,PTM:Phosphorylation has no effect on catalytic activity. ,similarity:Belongs to the type II topoisomerase family. ,subcellular location:Generally located in the nucleoplasm. ,subunit:Homodimer. Interacts with COPS5. ,
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细胞定位:
Cytoplasm . Nucleus , nucleoplasm . Nucleus . Nucleus , nucleolus .
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研究领域:
>>Platinum drug resistance
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货号: YT4701
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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