The antiserum was produced against synthesized peptide derived from human SOX12. AA range:71-120

Sox-12 Polyclonal Antibody detects endogenous levels of Sox-12 protein.

SOX12

Transcription factor SOX-12

SOX12 ;
SOX22 ;
Transcription factor SOX-12 ;
Protein SOX-22

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013],

Function:Binds to the sequence 5'-AACAAT-3'.,similarity:Contains 1 HMG box DNA-binding domain.,tissue specificity:Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.,

Nucleus .

Expressed most abundantly in the CNS (PubMed:9215677). Expressed in the heart, pancreas, thymus, testis and ovary (PubMed:9215677). Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes (PubMed:9215677).