Synthesized peptide derived from the Internal region of human SerpinA6.

SerpinA6 Polyclonal Antibody detects endogenous levels of SerpinA6 protein.

SERPINA6

Corticosteroid-binding globulin

SERPINA6 ;
CBG ;
Corticosteroid-binding globulin ;
CBG ;
Serpin A6 ;
Transcortin

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008],

Disease:Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.,Function:Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.,online information:Transcortin entry,PTM:Glycosylation in position Asn-260 is needed for steroid binding.,PTM:N-glycosylated; binds 5 oligosaccharide chains.,similarity:Belongs to the serpin family.,tissue specificity:Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.,

Secreted.