This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
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功能:
Function:Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.,similarity:Belongs to the peptidase C48 family.,tissue specificity:Broadly expressed, with highest levels in kidney and pancreas.,
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组织表达:
Broadly expressed, with highest levels in kidney and pancreas.