The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

Sck Polyclonal Antibody detects endogenous levels of Sck protein.

SHC2

SHC-transforming protein 2

SHC2 ;
SCK ;
SHCB ;
SHC-transforming protein 2 ;
Protein Sck ;
SHC-transforming protein B ;
Src homology 2 domain-containing-transforming protein C2 ;
SH2 domain protein C2

domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

Domain:The PID domain mediates binding to the TrkA receptor.,Function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

intracellular,cytosol,plasma membrane,

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>VEGF signaling pathway ;
>>Focal adhesion ;
>>Natural killer cell mediated cytotoxicity ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Relaxin signaling pathway ;
>>Growth hormone synthesis, secretion and action ;
>>Alcoholism ;
>>Bacterial invasion of epithelial cells ;
>>Glioma ;
>>Chronic myeloid leukemia ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer