SAE1 Rabbit pAb
-YT4207
主要信息
Target
SAE1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
38kD (Observed)
Conjugate/Modification
Unmodified
货号: YT4207
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
SAE1 Polyclonal Antibody detects endogenous levels of SAE1 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
38kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human AOS1. AA range:221-270
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特异性:
SAE1 Polyclonal Antibody detects endogenous levels of SAE1 protein.
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基因名称:
SAE1
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蛋白名称:
SUMO-activating enzyme subunit 1
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别名:
SAE1 ;
AOS1 ;
SUA1 ;
UBLE1A ;
SUMO-activating enzyme subunit 1 ;
Ubiquitin-like 1-activating enzyme E1A
AOS1 ;
SUA1 ;
UBLE1A ;
SUMO-activating enzyme subunit 1 ;
Ubiquitin-like 1-activating enzyme E1A
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背景:
SUMO1 activating enzyme subunit 1(SAE1) Homo sapiens Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010],
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功能:
Function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,tissue specificity:Expression level increases during S phase and drops in G2 phase (at protein level).,
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细胞定位:
Nucleus .
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组织表达:
Expression level increases during S phase and drops in G2 phase (at protein level).
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研究领域:
>>Ubiquitin mediated proteolysis
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信号通路
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货号: YT4207
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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