The antiserum was produced against synthesized peptide derived from human RAP1. AA range:203-252

RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein.

TERF2IP

Telomeric repeat-binding factor 2-interacting protein 1

TERF2IP ;
DRIP5 ;
RAP1 ;
PP8000 ;
Telomeric repeat-binding factor 2-interacting protein 1 ;
TERF2-interacting telomeric protein 1 ;
TRF2-interacting telomeric protein 1 ;
Dopamine receptor-interacting protein 5 ;
Repressor/activator protein 1 homol

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],

Function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TRF2 (but not TRF1) with its C-terminus.,tissue specificity:Ubiquitous. Highly expressed.,

Nucleus . Cytoplasm . Chromosome . Chromosome, telomere . Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. .

Ubiquitous. Highly expressed.