Synthesized peptide derived from the N-terminal region of human PTP22.

PTP22 Polyclonal Antibody detects endogenous levels of PTP22 protein.

PTPN22

Tyrosine-protein phosphatase non-receptor type 22

PTPN22 ;
PTPN8 ;
Tyrosine-protein phosphatase non-receptor type 22 ;
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP ;
Lymphoid phosphatase ;
LyP ;
PEST-domain phosphatase ;
PEP

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009],

Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.,

Cytoplasm .

Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.