The antiserum was produced against synthesized peptide derived from human FOXH1. AA range:10-59

FAST-1/2 Polyclonal Antibody detects endogenous levels of FAST-1/2 protein.

FOXH1

Forkhead box protein H1

FOXH1 ;
FAST1 ;
FAST2 ;
Forkhead box protein H1 ;
Forkhead activin signal transducer 1 ;
Fast-1 ;
hFAST-1 ;
Forkhead activin signal transducer 2 ;
Fast-2

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008],

Domain:The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex.,Function:Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with the MH2 domains of SMAD2 and SMAD3.,tissue specificity:Ubiquitous.,

Nucleus.

Ubiquitous.