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DNA pol γ2 Rabbit pAb

-YT1370

2 5
主要信息
Target

DNA pol γ2

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

IHC, IF, ELISA

MW

55kD (Calculated)

Conjugate/Modification

Unmodified

货号: YT1370
规格
价格
货期
数量
200μL
¥3,780.00
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0

100μL
¥2,300.00
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40μL
¥960.00
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0

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详细信息
推荐稀释比
IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
DNA pol γ2 Polyclonal Antibody detects endogenous levels of DNA pol γ2 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
55kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human POLG2. AA range:291-340
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特异性:
DNA pol γ2 Polyclonal Antibody detects endogenous levels of DNA pol γ2 protein.
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基因名称:
POLG2
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蛋白名称:
DNA polymerase subunit gamma-2 mitochondrial
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别名:
POLG2 ;
MTPOLB ;
DNA polymerase subunit gamma-2 ;
mitochondrial ;
DNA polymerase gamma accessory 55 kDa subunit ;
p55 ;
Mitochondrial DNA polymerase accessory subunit ;
MtPolB ;
PolG-beta
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数据库链接:
Organism 基因 ID SwissProt
Human 11232; Q9UHN1;
Mouse Q9QZM2;
背景:
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009],
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功能:
Catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,Disease:Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.,Function:Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.,subunit:Heterotrimer composed of a catalytic subunit and an homodimer of accessory subunits.,
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细胞定位:
Mitochondrion.
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组织表达:
Cerebellum,Cervix,Ovary,
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货号: YT1370
规格
价格
货期
数量
200μL
¥3,780.00
现货

0

100μL
¥2,300.00
现货

0

40μL
¥960.00
现货

0

加入购物车

已收藏

收藏

定制服务咨询

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