The antiserum was produced against synthesized peptide derived from human ACTN1/2/3/4. AA range:21-70

Actinin-α1/2/3/4 Polyclonal Antibody detects endogenous levels of Actinin-α1/2/3/4 protein.

ACTN1/2/3/4

Alpha-actinin-1/2/3/4

ACTN1 ;
Alpha-actinin-1 ;
Alpha-actinin cytoskeletal isoform ;
F-actin cross-linking protein ;
Non-muscle alpha-actinin-1 ;
ACTN2 ;
Alpha-actinin-2 ;
Alpha-actinin skeletal muscle isoform 2 ;
F-actin cross-linking protein ;
ACTN3 ;
Alpha-actinin-3 ;
A

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins , including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells , the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions , where it is involved in binding actin to the membrane. In contrast , skeletal , cardiac , and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies , where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle , cytoskeletal , alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2008] ,

Function:F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. ,similarity:Belongs to the alpha-actinin family. ,similarity:Contains 1 actin-binding domain. ,similarity:Contains 2 CH (calponin-homology) domains. ,similarity:Contains 2 EF-hand domains. ,similarity:Contains 4 spectrin repeats. ,subcellular location:Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. ,subunit:Homodimer; antiparallel. Interacts with DDN , MYOZ2 , PDLIM2 , TTID and LPP. ,

Cytoplasm , cytoskeleton . Cytoplasm , myofibril , sarcomere , Z line . Cell membrane . Cell junction . Cell projection , ruffle . Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures. .

>>Focal adhesion ;
>>Adherens junction ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Shigellosis ;
>>Amoebiasis ;
>>Viral carcinogenesis ;
>>Systemic lupus erythematosus