The antiserum was produced against synthesized peptide derived from human SLC27A5. AA range:481-530

ACSVL6 Polyclonal Antibody detects endogenous levels of ACSVL6 protein.

SLC27A5

Bile acyl-CoA synthetase

SLC27A5 ;
ACSB ;
ACSVL6 ;
FACVL3 ;
FATP5 ;
Bile acyl-CoA synthetase ;
BACS ;
Bile acid-CoA ligase ;
BA-CoA ligase ;
BAL ;
Cholate--CoA ligase ;
Fatty acid transport protein 5 ;
FATP-5 ;
Fatty-acid-coenzyme A ligase ;
very long-chain 3 ;
Solute carrier fam

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA.,Catalytic activity:ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA.,Function:Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,tissue specificity:Predominantly expressed in liver.,

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome . Cell membrane ; Multi-pass membrane protein .

Predominantly expressed in liver.

>>Primary bile acid biosynthesis ;
>>Metabolic pathways ;
>>PPAR signaling pathway ;
>>Insulin resistance ;
>>Bile secretion