The antiserum was produced against synthesized peptide derived from human PKG2 around the phosphorylation site of Ser126. AA range:92-141

Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GVsAE

PRKG2

cGMP-dependent protein kinase 2

PRKG2 ;
PRKGR2 ;
cGMP-dependent protein kinase 2 ;
cGK 2 ;
cGK2 ;
cGMP-dependent protein kinase II ;
cGKII

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,

Apical cell membrane ; Lipid-anchor .

Highly concentrated in brain, lung and intestinal mucosa.

>>cGMP-PKG signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Thermogenesis ;
>>Long-term depression ;
>>Olfactory transduction ;
>>Regulation of lipolysis in adipocytes ;
>>Renin secretion ;
>>Salivary secretion