The antiserum was produced against synthesized peptide derived from human EPHA3/4/5 around the phosphorylation site of Tyr779/833. AA range:746-795

This antibody detects endogenous levels of EphA3/4/5 only when phosphorylated at Human:Y779/779/833, Mouse:Y779/779/672, Rat:Y780/-/835..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AAyTT

EPHA3/EPHA4/EPHA5

Ephrin type-A receptor 3/4/5

EPHA3 ;
ETK ;
ETK1 ;
HEK ;
TYRO4 ;
Ephrin type-A receptor 3 ;
EPH-like kinase 4 ;
EK4 ;
hEK4 ;
HEK ;
Human embryo kinase ;
Tyrosine-protein kinase TYRO4 ;
Tyrosine-protein kinase receptor ETK1 ;
Eph-like tyrosine kinase 1 ;
EPHA4 ;
HEK8 ;
SEK ;
TYRO1 ;
Ephri

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Widely expressed. Highest level in placenta.

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