The antiserum was produced against synthesized peptide derived from human Neuro D around the phosphorylation site of Ser274. AA range:240-289

Phospho-Neuro D (S274) Polyclonal Antibody detects endogenous levels of Neuro D protein only when phosphorylated at S274.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PLsPP

NEUROD1

Neurogenic differentiation factor 1

NEUROD1 ;
BHLHA3 ;
NEUROD ;
Neurogenic differentiation factor 1 ;
NeuroD ;
NeuroD1 ;
Class A basic helix-loop-helix protein 3 ;
bHLHa3

This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008],

Disease:Defects in NEUROD1 are the cause of maturity onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY [MIM:606391] is characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.,Function:Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.,PTM:Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with TCF3/E47. Interacts with RREB1.,

Cytoplasm . Nucleus . In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus. .

Eye,Retina,Rhabdomyosarcoma,

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