Synthesized peptide derived from human ZNT5 AA range: 106-156

This antibody detects endogenous levels of ZNT5 at Human/Mouse

SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879

ZNT5

Zinc transporter 5 ;
ZnT-5 ;
Solute carrier family 30 member 5 ;
ZnT-like transporter 1 ;
hZTL1 ;

This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6 , and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene , and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq , Oct 2011] ,

Function:Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes , alkaline phosphatases (ALPs) . Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate , thus , converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. ,induction:Increased intracellular zinc level , resulting from extracellular zinc supplementation , do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion. ,miscellaneous:The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP. ,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. ,subcellular location:Perimeter of granules , localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles. ,subunit:Heterooligomer. Interacts with ZNT6. ,tissue specificity:Ubiquitously expressed. Highly expressed in pancreas , liver and kidney. Expressed abundantly in insulin-containing beta cells , undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells. ,

Golgi apparatus , trans-Golgi network membrane ; Multi-pass membrane protein . Perimeter of granules , localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.