Synthesized peptide derived from human GALT2 AA range: 30-80

This antibody detects endogenous levels of GALT2 at Human/Mouse

GALNT2

GALT2

Polypeptide N-acetylgalactosaminyltransferase 2 ;
Polypeptide GalNAc transferase 2 ;
GalNAc-T2 ;
pp-GaNTase 2 ;
Protein-UDP acetylgalactosaminyltransferase 2 ;
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 ;
[Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]

This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Catalytic activity:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.,cofactor:Calcium.,cofactor:Manganese.,Domain:The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.,Domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,Function:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.,online information:GlycoGene database,online information:Polypeptide N-acetylgalactosaminyltransferase 2,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.,similarity:Contains 1 ricin B-type lectin domain.,subcellular location:Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.,tissue specificity:Widely expressed.,

Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted . Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.

Widely expressed.

>>Mucin type O-glycan biosynthesis ;
>>Other types of O-glycan biosynthesis ;
>>Metabolic pathways