Synthesized peptide derived from part region of human protein. AA range:1-73

DICER Polyclonal Antibody detects endogenous levels of protein.

DICER1 DICER HERNA KIAA0928

Endoribonuclease Dicer (Helicase with RNase motif) (Helicase MOI)

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Sep 2010] ,

cofactor:Binds 2 magnesium or manganese ions per subunit. ,Function:Required for formation of the RNA induced silencing complex (RISC) . Component of the RISC loading complex (RLC) , also known as the micro-RNA (miRNA) loading complex (miRLC) , which is composed of DICER1 , EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC , DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. ,online information:The dark side of RNA -Issue 87 of October 2007 ,similarity:Belongs to the helicase family. Dicer subfamily. ,similarity:Contains 1 Dicer dsRNA-binding fold domain. ,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain. ,similarity:Contains 1 helicase ATP-binding domain. ,similarity:Contains 1 helicase C-terminal domain. ,similarity:Contains 1 PAZ domain. ,similarity:Contains 2 RNase III domains. ,subunit:Component of the RISC loading complex (RLC) , or micro-RNA (miRNA) loading complex (miRLC) , which is composed of DICER1 , EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9 , EIF2C1 , PIWIL1 and PRKRA. Associates with the 60S ribosome. ,

Cytoplasm . Cytoplasm , perinuclear region .

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