UB2E3 Rabbit pAb
-YN1490
主要信息
Target
UB2E3
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
22kD (Observed)
Conjugate/Modification
Unmodified
货号: YN1490
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
UB2E3 Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
22kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from part region of human protein
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特异性:
UB2E3 Polyclonal Antibody detects endogenous levels of protein.
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基因名称:
UBE2E3 UBCE4 UBCH9
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蛋白名称:
Ubiquitin-conjugating enzyme E2 E3 (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
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背景:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013],
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功能:
Catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,Function:Catalyzes the covalent attachment of ubiquitin to other proteins. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subcellular location:Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.,subunit:The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus (By similarity). Interacts with NEDD4L.,tissue specificity:Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.,
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细胞定位:
Nucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
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组织表达:
Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
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研究领域:
>>Ubiquitin mediated proteolysis
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信号通路
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货号: YN1490
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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