BRAT1 (PT0803R) PT™ Rabbit mAb
-YM8898
主要信息
Target
BRAT1
Host Species
Rabbit
Reactivity
Human
Applications
WB, IF, ICC, FC, IP
MW
90kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8898
规格
价格
货期
数量
200μL
￥3,780.00
一周
0
100μL
￥2,300.00
一周
0
40μL
￥960.00
一周
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:1000-5000; ICC/IF 1:100-300; FC 1:100-300; IP 1:50-100
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
实测条带
90kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0803R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
BRAT1;BAAT1;C7orf27
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蛋白名称:
BRCA1-associated ATM activator 1;BRCA1-associated protein required for ATM activation protein 1;
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别名:
BRAT1 ;
BAAT1 ;
C7orf27 ;
BRCA1-associated ATM activator 1 ;
BRCA1-associated protein required for ATM activation protein 1 ;
BAAT1 ;
C7orf27 ;
BRCA1-associated ATM activator 1 ;
BRCA1-associated protein required for ATM activation protein 1 ;
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背景:
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
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功能:
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994}.
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细胞定位:
Nucleus. Cytoplasm. Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner..
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组织表达:
Ubiquitously expressed. {ECO:0000269|PubMed:16452482}.
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文献引用（{{totalcount}}）
货号: YM8898
规格
价格
货期
数量
200μL
￥3,780.00
一周
0
100μL
￥2,300.00
一周
0
40μL
￥960.00
一周
0
加入购物车
已收藏
收藏
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