Synthesized peptide derived from human TGF β1 Polyclonal

This antibody detects endogenous levels of TGF β at Human, Mouse,Rat

TGFB1 TGFB

Transforming growth factor beta-1, TGF-β1, TGF b

Caspase-3 ;
CASP-3 ;
Apopain ;
Cysteine protease CPP32 ;
CPP-32 ;
Protein Yama ;
SREBP cleavage activity 1 ;
SCA-1 ;
[Cleaved into: Caspase-3 subunit p17 ;
Caspase-3 subunit p12]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-1]: Secreted .

>>Platinum drug resistance ;
>>MAPK signaling pathway ;
>>p53 signaling pathway ;
>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Natural killer cell mediated cytotoxicity ;
>>IL-17 signaling pathway ;
>>TNF signaling pathway ;
>>Serotonergic synapse ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Toxoplasmosis ;
>>Amoebiasis ;
>>Tuberculosis ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Colorectal cancer ;
>>Small cell lung cancer ;
>>Viral myocarditis ;
>>Lipid and atherosclerosis