Purified recombinant human CBR1 protein fragments expressed in E.coli

This antibody detects endogenous levels of CBR1 and does not cross-react with related proteins.

cbr1

15 hydroxyprostaglandin dehydrogenase [NADP ] ;
15-hydroxyprostaglandin dehydrogenase [NADP ] ;
Carbonyl reductase [NADPH] 1 ;
CBR 1 ;
CBR1 ;
CBR1_HUMAN ;
CRN ;
NADPH dependent carbonyl reductase 1 ;
NADPH-dependent carbonyl reductase 1 ;
Prostaglandin 9 ketoreductase ;
Prostaglandin 9-ketoreductase ;
Prostaglandin E ;
2 ;
9 reductase ;
Prostaglandin-E ;
2 ;
9-reductase ;
SDR21C1.

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013],

Catalytic activity:(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.,Catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.,Catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,Function:Catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. Can convert prostaglandin E2 to prostaglandin F2-alpha.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Monomer.,

Cytoplasm .

Expressed in kidney (at protein level).

>>Arachidonic acid metabolism ;
>>Folate biosynthesis ;
>>Metabolism of xenobiotics by cytochrome P450 ;
>>Metabolic pathways ;
>>Chemical carcinogenesis - DNA adducts ;
>>Chemical carcinogenesis - reactive oxygen species