The antiserum was produced against synthesized peptide derived from human PAR1. AA range:23-72

Cleaved-Thrombin R (S42) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin R protein resulting from cleavage adjacent to S42.

F2R

Proteinase-activated receptor 1

F2R ;
CF2R ;
PAR1 ;
TR ;
Proteinase-activated receptor 1 ;
PAR-1 ;
Coagulation factor II receptor ;
Thrombin receptor

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

Function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,

Cell membrane; Multi-pass membrane protein.

Platelets and vascular endothelial cells.

>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>PI3K-Akt signaling pathway ;
>>Complement and coagulation cascades ;
>>Platelet activation ;
>>Regulation of actin cytoskeleton ;
>>Pathogenic Escherichia coli infection ;
>>Pathways in cancer