The antiserum was produced against synthesized peptide derived from human ITGA5. AA range:876-925

Cleaved-Integrin α5 LC (E895) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α5 LC protein resulting from cleavage adjacent to E895.

ITGA5

Integrin alpha-5

ITGA5 ;
FNRA ;
Integrin alpha-5 ;
CD49 antigen-like family member E ;
Fibronectin receptor subunit alpha ;
Integrin alpha-F ;
VLA-5 ;
CD antigen CD49e

integrin subunit alpha 5(ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],

Function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .

Liver,Placenta,

>>Phagosome ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Hematopoietic cell lineage ;
>>Regulation of actin cytoskeleton ;
>>Bacterial invasion of epithelial cells ;
>>Shigellosis ;
>>Pertussis ;
>>Yersinia infection ;
>>Human papillomavirus infection ;
>>Herpes simplex virus 1 infection ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy