The antiserum was produced against synthesized peptide derived from human PPGB. AA range:277-326

Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin A 32k protein resulting from cleavage adjacent to R326.

CTSA PPGB

Lysosomal protective protein

CTSA ;
PPGB ;
Lysosomal protective protein ;
Carboxypeptidase C ;
Carboxypeptidase L ;
Cathepsin A ;
Protective protein cathepsin A ;
PPCA ;
Protective protein for beta-galactosidase ;
[Cleaved into: Lysosomal protective protein 32 kDa chain ;
Lysosomal protective protein 20 kDa chain]

This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015],

Catalytic activity:Release of a C-terminal amino acid with broad specificity.,Disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,Function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.,

Lysosome.

Brain,Liver,Placenta,Platelet,Skin,Uterus,

>>Lysosome ;
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