Calpain 1 (PT1874R) PT™ Rabbit mAb
-YM960127
主要信息
Target
CAN1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
82kD (Calculated)
75kD (Observed)
Conjugate/Modification
Unmodified
货号: YM960127
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
82kD
实测条带
75kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT1874R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
Endogenous
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基因名称:
CAPN1 CANPL1 PIG30
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蛋白名称:
Calpain-1 catalytic subunit (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
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背景:
The calpains , calcium-activated neutral proteases , are nonlysosomal , intracellular cysteine proteases. The mammalian calpains include ubiquitous , stomach-specific , and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large , catalytic subunits associated with a common small , regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme , calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq , Nov 2010] ,
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功能:
Catalytic activity:Broad endopeptidase specificity. ,cofactor:Binds 3 calcium ions. ,enzyme regulation:Activated by micromolar concentrations of calcium and inhibited by calpastatin. ,Function:Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. ,online information:Calpain ,similarity:Belongs to the peptidase C2 family. ,similarity:Contains 1 calpain catalytic domain. ,similarity:Contains 4 EF-hand domains. ,subcellular location:Translocates to the plasma membrane upon Ca (2+) binding. ,subunit:Forms a heterodimer with a small (regulatory) subunit (CAPNS1) . ,tissue specificity:Ubiquitous. ,
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细胞定位:
Cytoplasm . Cell membrane . Translocates to the plasma membrane upon Ca (2+) binding. In granular keratinocytes and in lower corneocytes , colocalizes with FLG and FLG2 (PubMed:21531719) . .
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组织表达:
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研究领域:
>>Protein processing in endoplasmic reticulum ;
>>Apoptosis ;
>>Necroptosis ;
>>Cellular senescence ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis
>>Apoptosis ;
>>Necroptosis ;
>>Cellular senescence ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis
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信号通路
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Necroptosis
Cellular Processes >> Cell growth and death >> Cellular senescence
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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货号: YM960127
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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