详细信息
组成
Liquid in PBS
来源
E.coli
纯度
SDS-PAGE >90%
储存
-20°C/6 month,-80°C for long storage
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
序列:
Amino acid: 1-72, with his-MBP tag.
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基因名称:
MAP1LC3B
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蛋白名称:
LC3B protein
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别名:
Microtubule-associated proteins 1A/1B light chain 3B ;
Autophagy-related protein LC3 B ;
Autophagy-related ubiquitin-like modifier LC3 B ;
MAP1 light chain 3-like protein 2 ;
MAP1A/MAP1B light chain 3 B ;
MAP1A/MAP1B LC3 B ;
Microtubule-associated protein 1 light chain 3 beta ;
Autophagy-related protein LC3 B ;
Autophagy-related ubiquitin-like modifier LC3 B ;
MAP1 light chain 3-like protein 2 ;
MAP1A/MAP1B light chain 3 B ;
MAP1A/MAP1B LC3 B ;
Microtubule-associated protein 1 light chain 3 beta ;
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背景:
caution:PubMed:12740394 has shown that the protein is cleaved at Lys-122 but PubMed:15355958 has shown that the cleavage site is at Gly-120 as in other mammalian orthologs. ,function:Probably involved in formation of autophagosomal vacuoles (autophagosomes) . ,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7 , transferred to ATG3 and conjugated to phospholipid to form LC3-II. ,similarity:Belongs to the MAP1 LC3 family. ,subcellular location:LC3-II binds to the autophagic membranes. ,subunit:3 different light chains , LC1 , LC2 and LC3 , can associate with MAP1A and MAP1B proteins. ,tissue specificity:Most abundant in heart , brain , skeletal muscle and testis. Little expression observed in liver. ,
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功能:
proteolysis , autophagy , macromolecule catabolic process , modification-dependent protein catabolic process , protein catabolic process , modification-dependent macromolecule catabolic process , cellular protein catabolic process , cellular macromolecule catabolic process , proteolysis involved in cellular protein catabolic process ,
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细胞定位:
Cytoplasmic vesicle , autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Mitochondrion membrane ; Lipid-anchor . Cytoplasm , cytoskeleton . Cytoplasmic vesicle . LC3-II binds to the autophagic membranes. LC3-II localizes with the mitochondrial inner membrane during Parkin-mediated mitophagy (PubMed:28017329) . Localizes also to discrete punctae along the ciliary axoneme. .
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Cellular Processes >> Cell growth and death >> Ferroptosis
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
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