Synthesized peptide derived from human Integrin β7. at AA range: 671-720

Integrin β7 Polyclonal Antibody detects endogenous levels of Integrin β7

ITGB7

Integrin β7

Integrin beta-7 ;
Gut homing receptor beta subunit ;

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin , a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described , but their full-length nature is not known. [provided by RefSeq , Sep 2013] ,

Domain:Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS) , the metal ion-dependent adhesion site (MIDAS) , and the adjacent to MIDAS site (ADMIDAS) . In the absence of a ligand or in calcium-dependent binding , only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding. ,Function:Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) . Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin , an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1 , and L-D-V in fibronectin. Binds to HIV-1 gp120 , thereby allowing the virus to enter GALT , which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. ,induction:Integrin alpha-E/beta-7 is induced by TGFB1. ,similarity:Belongs to the integrin beta chain family. ,similarity:Contains 1 VWFA domain. ,subunit:Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1 , VCAM , fibronectin , and may also interact with HIV-1 gp120. ,tissue specificity:Expressed in a variety of leukocyte lines. ,

Membrane; Single-pass type I membrane protein.

>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Cell adhesion molecules ;
>>Intestinal immune network for IgA production ;
>>Regulation of actin cytoskeleton ;
>>Human papillomavirus infection ;
>>Transcriptional misregulation in cancer ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy