FGFR-4 Rabbit pAb
-YT5715
主要信息
Target
FGFR-4
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
85kD (Observed)
Conjugate/Modification
Unmodified
货号: YT5715
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
FGFR-4 Polyclonal Antibody detects endogenous levels of FGFR-4 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
85kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from the Internal region of human FGFR4. AA range:91-140
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特异性:
FGFR-4 Polyclonal Antibody detects endogenous levels of FGFR-4 protein.
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基因名称:
FGFR4
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蛋白名称:
Fibroblast growth factor receptor 4
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别名:
FGFR4 ;
JTK2 ;
TKF ;
Fibroblast growth factor receptor 4 ;
FGFR-4 ;
CD334
JTK2 ;
TKF ;
Fibroblast growth factor receptor 4 ;
FGFR-4 ;
CD334
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背景:
The protein encoded by this gene is a member of the fibroblast growth factor receptor family , where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region , composed of three immunoglobulin-like domains , a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors , setting in motion a cascade of downstream signals , ultimately influencing mitogenesis and differentiation. The genomic organization of this gene , compared to members 1-3 , encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed , there is no evidence that the C-terminal half of the IgII
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19. ,PTM:Glycosylated (By similarity) . Phosphorylated on tyrosine residue (By similarity) . Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains. ,subcellular location:Isoform 2 may be secreted. ,subunit:Interacts with KLB. ,tissue specificity:Expressed in gastrointestinal epithelial cells , pancreas , and gastric and pancreatic cancer cell lines. ,
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细胞定位:
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes , and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm .
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研究领域:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>Endocytosis ;
>>PI3K-Akt signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Regulation of actin cytoskeleton ;
>>Pathways in cancer
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>Endocytosis ;
>>PI3K-Akt signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Regulation of actin cytoskeleton ;
>>Pathways in cancer
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信号通路
Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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货号: YT5715
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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