The antiserum was produced against synthesized peptide derived from human PIK3R5. AA range:695-744

PI 3-kinase p101 Polyclonal Antibody detects endogenous levels of PI 3-kinase p101 protein.

PIK3R5

Phosphoinositide 3-kinase regulatory subunit 5

PIK3R5 ;
Phosphoinositide 3-kinase regulatory subunit 5 ;
PI3-kinase regulatory subunit 5 ;
PI3-kinase p101 subunit ;
Phosphatidylinositol 4 ;
5-bisphosphate 3-kinase regulatory subunit ;
PtdIns-3-kinase regulatory subunit ;
Protein FOAP-2 ;
PtdIns-

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011],

Domain:The heterodimerization region allows the binding to the catalytic subunit.,enzyme regulation:Greatly activated by G gamma proteins.,Function:Regulatory subunit of the PI3K gamma complex.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins.,tissue specificity:Highly expressed in leukocytes, followed by spleen, lymph node, thymus ans bone marrow.,

Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein . Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. .

>>cGMP-PKG signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>Apelin signaling pathway ;
>>Platelet activation ;
>>Cholinergic synapse ;
>>Oxytocin signaling pathway ;
>>Toxoplasmosis ;
>>Kaposi sarcoma-associated herpesvirus infection