The antiserum was produced against synthesized peptide derived from human Caspase-7. AA range:45-94

Caspase-7 Polyclonal Antibody detects endogenous levels of Caspase-7 protein.

CASP7

Caspase7

CASP7 ;
MCH3 ;
Caspase-7 ;
CASP-7 ;
Apoptotic protease Mch-3 ;
CMH-1 ;
ICE-like apoptotic protease 3 ;
ICE-LAP3

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits , large and small , that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10 , is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq , May 2012] ,

Catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-. ,enzyme regulation:Inhibited by isatin sulfonamides. ,Function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. ,PTM:Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3 , and vice versa , also occur. ,similarity:Belongs to the peptidase C14A family. ,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers , each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. ,tissue specificity:Highly expressed in lung , skeletal muscle , liver , kidney , spleen and heart , and moderately in testis. No expression in the brain. ,

Cytoplasm.

>>Apoptosis ;
>>Apoptosis - multiple species ;
>>TNF signaling pathway ;
>>Non-alcoholic fatty liver disease ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Pathways in cancer ;
>>Lipid and atherosclerosis