MKP-2 (PT1722R) PT™ Rabbit mAb
-YM9564
主要信息
Target
MKP-2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, IP, ELISA
MW
43kD (Calculated)
40kD (Observed)
Conjugate/Modification
Unmodified
货号: YM9564
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
43kD
实测条带
40kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT1722R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
DUSP4
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蛋白名称:
Dual specificity protein phosphatase 4
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别名:
DUSP4 ;
MKP2 ;
VH2 ;
Dual specificity protein phosphatase 4 ;
Dual specificity protein phosphatase hVH2 ;
Mitogen-activated protein kinase phosphatase 2 ;
MAP kinase phosphatase 2 ;
MKP-2
MKP2 ;
VH2 ;
Dual specificity protein phosphatase 4 ;
Dual specificity protein phosphatase hVH2 ;
Mitogen-activated protein kinase phosphatase 2 ;
MAP kinase phosphatase 2 ;
MKP-2
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背景:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been obser
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功能:
Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,
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细胞定位:
Nucleus .
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组织表达:
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研究领域:
>>MAPK signaling pathway
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货号: YM9564
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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