β2-MG (PT1216R) PT™ Rabbit mAb
-YM9058
主要信息
Target
B2MG
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
14kD (Calculated)
12kD (Observed)
Conjugate/Modification
Unmodified
货号: YM9058
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:2000-1:10000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note:For IHC,wesuggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
14kD
实测条带
12kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT1216R
同种型
IgG,Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
B2M CDABP0092 HDCMA22P
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蛋白名称:
Beta-2-microglobulin
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背景:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014],
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功能:
Disease:Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.,Function:Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.,online information:Beta-2-microglobulin entry,PTM:Glycation of Ile-21 is observed in long-term hemodialysis patients.,similarity:Belongs to the beta-2-microglobulin family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,
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细胞定位:
Secreted . Cell surface . Detected in serum and urine (PubMed:1336137, PubMed:7554280). .; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553). .
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研究领域:
>>Antigen processing and presentation ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection
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文献引用（{{totalcount}}）
货号: YM9058
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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