PU.1 (PT0951R) PT™ Rabbit mAb
-YM8650
主要信息
Target
PU.1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
31kD (Calculated)
42kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8650
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
31kD
实测条带
42kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0951R
同种型
IgG,Kappa
相关产品
Primary Antibodies
PU.1 Rabbit pAb
YT3906
预览→
ELISA Kits
Total PU.1 Cell-Based Colorimetric ELISA Kit
KA3554C
预览→
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
特异性:
Endogenous
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基因名称:
SPI1
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蛋白名称:
Transcription factor PU.1
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别名:
SPI1 ;
Transcription factor PU.1 ;
31 kDa-transforming protein
Transcription factor PU.1 ;
31 kDa-transforming protein
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背景:
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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功能:
Function:Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.,induction:Highly expressed in both FV-P and FV-A-induced erythro-leukemia cell lines that have undergone rearrangements of the Spi-1 gene due to the insertion of SFFV.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,subunit:Binds DNA as a monomer. Interacts with RUNX1 and SPIB. Interacts with CEBPD and NONO.,
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细胞定位:
Nucleus .
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研究领域:
>>Osteoclast differentiation ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
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信号通路
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货号: YM8650
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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