Cleaved MMP-10 (Phe99) Rabbit pAb
-YC0059
主要信息
Target
MMP-10
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, ELISA
MW
43kD (Observed)
Conjugate/Modification
Unmodified
货号: YC0059
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
43kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human MMP10. AA range:80-129
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特异性:
Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99.
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基因名称:
MMP10
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蛋白名称:
Stromelysin-2
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别名:
MMP10 ;
STMY2 ;
Stromelysin-2 ;
SL-2 ;
Matrix metalloproteinase-10 ;
MMP-10 ;
Transin-2
STMY2 ;
Stromelysin-2 ;
SL-2 ;
Matrix metalloproteinase-10 ;
MMP-10 ;
Transin-2
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背景:
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016],
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功能:
Catalytic activity:Similar to stromelysin 1, but action on collagen types III, IV and V is weak.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Calcium.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,Function:Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,
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细胞定位:
Secreted, extracellular space, extracellular matrix .
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组织表达:
Coronary artery,Ovary,
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货号: YC0059
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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