TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein ;
TNFR1-associated DEATH domain protein ;
TNFRSF1A-associated via death domain ;

domain:Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1.,function:Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.,similarity:Contains 1 death domain.,subunit:Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.,tissue specificity:Found in all examined tissues.,

apoptosis, induction of apoptosis, cell death, activation of pro-apoptotic gene products, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, cytokine-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway, regulation of hair cycle, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade, regulation of epidermis development, positive regulation of epidermis development, positive regulation of developmental process, positive regulation of multicellular organismal process, regulation of hair follicle development, positive regulation of hair follicle development,

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Shuttles between the cytoplasm and the nucleus. .

Found in all examined tissues.