Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TIE1

Tyrosine-protein kinase receptor Tie-1

TIE1 ;
TIE ;
Tyrosine-protein kinase receptor Tie-1

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Probable protein tyrosine-kinase transmembrane receptor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 fibronectin type-III domains.,tissue specificity:Specifically expressed in developing vascular endothelial cells.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, membrane fusion,cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, mesoderm development, response to nutrient, response to extracellular stimulus, membrane organization, phosphorylation, negative regulation of angiogenesis, regulation of cell migration, negative regulation of cell migration, response to nutrient levels, response to retinoic acid, response to vitamin A, response to vitamin, regulation of locomotion, negative regulation of locomotion, plasma membrane fusion,regulation of angiogenesis, regulation of cell motion, negative regulation of cell motion,

Cell membrane ; Single-pass type I membrane protein .

Specifically expressed in developing vascular endothelial cells.