Synthesized peptide derived from human Shc3 (Phospho-Tyr424)

This antibody detects endogenous levels of Shc3 (Phospho-Tyr424) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PTyVN

SHC3 NSHC SHCC

Shc3 (Phospho-Tyr424)

SHC-transforming protein 3 ;
Neuronal Shc ;
N-Shc ;
Protein Rai ;
SHC-transforming protein C ;
Src homology 2 domain-containing-transforming protein C3 ;
SH2 domain protein C3 ;

Function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. ,PTM:Tyrosine phosphorylated. ,similarity:Contains 1 PID domain. ,similarity:Contains 1 SH2 domain. ,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated , binds to GRB2. Interacts with activated EGF receptors. ,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues , except in pancreas. Highly expressed in the cerebral cortex , frontal and temporal lobes , occipital pole , hippocampus , caudate nucleus and amygdala. Expressed at low level in the cerebellum , medulla and spinal cord. ,

cytosol ,plasma membrane ,

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Focal adhesion ;
>>Natural killer cell mediated cytotoxicity ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Relaxin signaling pathway ;
>>Growth hormone synthesis , secretion and action ;
>>Alcoholism ;
>>Bacterial invasion of epithelial cells ;
>>Glioma ;
>>Chronic myeloid leukemia ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer