Synthesized peptide derived from human IRF5 (Phospho-Ser437)

This antibody detects endogenous levels of IRF5 (Phospho-Ser437) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SWsAD

IRF5

IRF5 (Phospho-Ser437)

Interferon regulatory factor 5 ;
IRF-5 ;

This gene encodes a member of the interferon regulatory factor (IRF) family , a group of transcription factors with diverse roles , including virus-mediated activation of interferon , and modulation of cell growth , differentiation , apoptosis , and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene , and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq , Mar 2010] ,

Disease:Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14) [MIM:612245]. Inflammatory bowel disease (IBD) is a form of remitting Crohn disease (CD) . CD may involve any part of the gastrointestinal tract , but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. CD is commonly classified as an autoimmune disease. ,Disease:Genetic variations in IRF5 are associated with susceptibility to rheumatoid arthritis (RA) [MIM:180300]. Rheumatoid arthritis is a complex , multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction. ,Disease:Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10 (SLEB10) [MIM:612251]. Systemic lupus erythematosus (SLE) is a chronic , inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin , joints , kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. ,similarity:Belongs to the IRF family. ,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain. ,

Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation , translocates to the nucleus. .

>>Toll-like receptor signaling pathway